ARP Rheumatology
ARP Rheumatology
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Article

ARP Rheumatology
Review article

Monocyte chemoattractant protein-1 promoter-2518 G allele increases renal damage in systemic lupus erythematosus patients: result from a meta-analysis

Authors

Luo X, Wei Q, Chen L, Yang M, Li K, Liu Y, Yuan G

Abstract

Objective: Reports about the monocyte chemoattractant protein-1 (MCP-1) promoter-2518A/G polymorphism and systemic lupus erythematosus (SLE) were controversial. This study aimed to assess the association between MCP-1 promoter-2518A/G polymorphism and SLE via meta-analysis. Methods: Eligible studies were identified by searching the PubMed database for studies published before September 2015. Thirteen studies and data from 2,654 patients with SLE and 2,626 healthy controls were included in the study. Results: We performed a meta-analysis of the data extracted. We found that the ratios of renal disease in patients who carried the G allele (AG and GG genotypes) were higher than those in patients who did not carry G allele. Conclusion: We concluded that MCP-1 promoter-2518 G allele was a risk factor for renal damages in patients with SLE.

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Publication:

2018-04-27

Cite:

Xiong-Yan Luo, Qin Wei, Long Chen, Ming-Hui Yang, Kuen Li, Yi Liu, Guo-Hua Yuan. Monocyte chemoattractant protein-1 promoter-2518 G allele increases renal damage in systemic lupus erythematosus patients: result from a meta-analysis.
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