Article
ARP Rheumatology
Pachymeningitis and cerebral granuloma in granulomatosis with polyangiitis: is rituximab a promising treatment option?
Abstract
Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease characterized by granulomatous inflammation involving upper and lower respiratory tract, kidneys and peripheral nervous system. However, central nervous system involvement is uncommon and frequently refractory to classical therapy. Rituximab has emerged as promising alternative, but published reports are scarce. We report a case of pachymeningitis and cerebral granuloma in a patient with a history of severe generalized GPA, treated with rituximab. This case illustrates the complexity of the management of neurologic manifestations and provides insight into the potential utility of rituximab in this condition.
Share
Publication:
2016-11-09
Pubmed:
Cite:
Carlos Costa, Tânia Santiago, Joana Espirito-Santo, João Rovisco, Jorge Silva, Armando Malcata. Pachymeningitis and cerebral granuloma in granulomatosis with polyangiitis: is rituximab a promising treatment option?. ARP, nº1, Jan/Mar 2017:82-87. PMID: 28371573
Copy citation
Copy citation